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KMID : 1123920210350020064
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Korean Journal of Oriental Physiology and Pathology
2021 Volume.35 No. 2 p.64 ~ p.70
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Anti-Colitic Effects of Herbal Medicine HPL-01 on Dextran Sulfate Sodium Induced Ulcerative Colitis in Rat
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Jo Hyoung-Kwon
Kim Dae-Sung
Cho Seong-Wan
Shin Na-Rae
Park Young-Mi
Lee Hak-Yong
Shiin Dong-Yeop
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Abstract
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This study aimed to investigate the anti-inflammatory effects of herbal complex HPL-01 on dextran sodium sulfate(DSS) induced ulcerative colitis in rat. Adult male Sprague?Dawley rats were randomized and divided into six groups. Five groups, excluding the normal group, were orally administered orally HPL-01(50, 100, or 200 mg/kg) for 21 days, and acute colitis was induced during the last 7 days by 4% DSS in the drinking water. The HPL-01 administered DSS-treated rats exhibited significantly reduced colon macroscopic damage index and increased body weight and colonic length 7 days after DSS treatment. Additionally, these rats showed lower serum levels of the pro-inflammatory cytokines TNF-α and IL-6 than those treated only with DSS. HPL-01(100 or 200 mg/kg) also attenuated the DSS-induced increase in the number of white blood cells, granulocytes, and mid cells and improved intestinal damage. Taken together, these results suggest that HPL-01 is a promising anti-inflammatory agent that may be in the treatment of colitis.
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KEYWORD
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Herbal complex HPL-01, Ulcerative colitis, Dextran sulfate sodium, Colon length, TNF-α, IL-6
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